Health Topics: /Arteriovenous malformation (AVM)

AVM stands for Arteriovenous Malformation. An AVM is a tangle of abnormal and poorly formed blood vessels (arteries and veins). They have a higher rate of bleeding than normal vessels. AVMs can occur anywhere in the body. Brain AVMs are of special concern because of the damage they cause when they bleed.

A brain arteriovenous malformation (AVM) is a tangle of abnormal blood vessels connecting arteries and veins in the brain.

The arteries are responsible for taking oxygen-rich blood from the heart to the brain. Veins carry the oxygen-depleted blood back to the lungs and heart. A brain AVM disrupts this vital process.

An arteriovenous malformation can develop anywhere in your body but occurs most often in the brain or spine. Even so, brain AVMs are rare and affect less than 1 percent of the population.

The cause of AVMs is not clear. Most people are born with them, but they can occasionally form later in life. They are rarely passed down among families genetically.

Some people with brain AVMs experience signs and symptoms, such as headache or seizures. AVMs are commonly found after a brain scan for another health issue or after the blood vessels rupture and cause bleeding in the brain (hemorrhage).

Once diagnosed, a brain AVM can often be treated successfully to prevent complications, such as brain damage or stroke.

Symptoms

A brain arteriovenous malformation may not cause any signs or symptoms until the AVM ruptures, resulting in bleeding in the brain (hemorrhage). In about half of all brain AVMs, hemorrhage is the first sign.

But some people with brain AVM may experience signs and symptoms other than bleeding related to the AVM.

In people without hemorrhage, signs and symptoms of a brain AVM may include:

  • Seizures
  • Headache or pain in one area of the head
  • Muscle weakness or numbness in one part of the body

Some people may experience more-serious neurological signs and symptoms, depending on the location of the AVM, including:

  • Severe headache
  • Weakness, numbness or paralysis
  • Vision loss
  • Difficulty speaking
  • Confusion or inability to understand others
  • Severe unsteadiness

Symptoms may begin at any age but usually emerge between ages 10 and 40. Brain AVMs can damage brain tissue over time. The effects slowly build up and often cause symptoms in early adulthood.

Once you reach middle age, however, brain AVMs tend to remain stable and are less likely to cause symptoms.

Some pregnant women may have worsened symptoms due to changes in blood volume and blood pressure.

One severe type of brain AVM, called a vein of Galen defect, causes signs and symptoms that emerge soon or immediately after birth. The major blood vessel involved in this type of brain AVM can cause fluid to build up in the brain and the head to swell. Signs and symptoms include swollen veins that are visible on the scalp, seizures, failure to thrive and congestive heart failure.

When to see a doctor

Seek immediate medical attention if you notice any signs or symptoms of a brain AVM, such as seizures, headaches or other symptoms. A bleeding brain AVM is life-threatening and requires emergency medical attention.

Causes

The cause of brain AVM is unknown, but researchers believe most brain AVMs emerge during fetal development.

Normally, your heart sends oxygen-rich blood to your brain through arteries. The arteries slow blood flow by passing it through a series of progressively smaller networks of blood vessels, ending with the smallest blood vessels (capillaries). The capillaries slowly deliver oxygen through their thin, porous walls to the surrounding brain tissue.

The oxygen-depleted blood then passes into small blood vessels and then into larger veins that drain the blood from your brain, returning it to your heart and lungs to get more oxygen.

The arteries and veins in an AVM lack this supporting network of smaller blood vessels and capillaries. Instead, the abnormal connection causes blood to flow quickly and directly from your arteries to your veins, bypassing the surrounding tissues.

Risk factors

Anyone can be born with a brain AVM, but these factors may be a risk:

  • Being male. AVMs are more common in males.
  • Having a family history.Cases of AVMs in families have been reported, but it's unclear if there's a certain genetic factor or if the cases are only coincidental. It's also possible to inherit other medical conditions that predispose you to having vascular malformations such as AVMs.

Complications

Complications of a brain AVM include:

  • Bleeding in the brain (hemorrhage).An AVM puts extreme pressure on the walls of the affected arteries and veins, causing them to become thin or weak. This may result in the AVM rupturing and bleeding into the brain (a hemorrhage).

    This risk of a brain AVM bleeding ranges around 2 percent each year. The risk of hemorrhage may be higher for certain types of AVMs, or if you have experienced previous AVM ruptures.

    Some hemorrhages associated with AVMs go undetected because they cause no major brain damage or symptoms, but potentially life-threatening bleeding episodes may occur.

    Brain AVMs account for about 2 percent of all hemorrhagic strokes each year and are often the cause of hemorrhage in children and young adults who experience brain hemorrhage.

  • Reduced oxygen to brain tissue. With an AVM, blood bypasses the network of capillaries and flows directly from arteries to veins. Blood rushes quickly through the altered path because it isn't slowed down by channels of smaller blood vessels.

    Surrounding brain tissues can't easily absorb oxygen from the fast-flowing blood. Without enough oxygen, brain tissues weaken or may die off completely. This results in stroke-like symptoms, such as difficulty speaking, weakness, numbness, vision loss or severe unsteadiness.

  • Thin or weak blood vessels. An AVM puts extreme pressure on the thin and weak walls of the blood vessels. A bulge in a blood vessel wall (aneurysm) may develop and become susceptible to rupture.
  • Brain damage. As you grow, your body may recruit more arteries to supply blood to the fast-flowing AVM. As a result, some AVMs may get bigger and displace or compress portions of the brain. This may prevent protective fluids from flowing freely around the hemispheres of the brain.

    If fluid builds up, it can push brain tissue up against the skull (hydrocephalus).Arteriovenous malformation (AVM) is an abnormal connection between arteries and veins, bypassing the capillary system. This vascular anomaly is widely known because of its occurrence in the central nervous system, but can appear in any location. Although many AVMs are asymptomatic, they can cause intense pain or bleeding or lead to other serious medical problems.

    AVMs are usually congenital and belong to the RASopathies. The genetic transmission patterns of AVM, if any, are unknown. AVM is not generally thought to be an inherited disorder, unless in the context of a specific hereditary syndrome.

    Signs and symptoms

    Symptoms of AVM vary according to the location of the malformation. Roughly 88%[1] of people affected with AVM are asymptomatic; often the malformation is discovered as part of an autopsy or during treatment of an unrelated disorder (called in medicine "an incidental finding"); in rare cases its expansion or a micro-bleed from an AVM in the brain can cause epilepsy, neurological deficit or pain.

    The most general symptoms of a cerebral AVM include headache and epilepsy, with more specific symptoms occurring that normally depend on the location of the malformation and the individual. Such possible symptoms include:

    Cerebral AVMs may present in a number of ways

    • Hemorrhage (45% of cases)
      • Acute onset of severe headache. May be described as the worst headache of the patient's life. Depending on the location of hemorrhage, may be associated with new fixed neurologic deficit. In unruptured brain AVMs, the risk of spontaneous hemorrhage may be as low as 1% per year. After a first rupture, the annual bleeding risk may increase to more than 5%.
    • Seizure or brain seizure(46%) Depending on place of avm it can cause loss of vision in one place.
    • Headache (34%)
    • Progressive neurologic deficit (21%)
      • May be caused by mass effect or venous dilatations. Presence and nature of deficit depend on location of lesion and the draining veins.
    • Pediatric patients
      • Heart failure
      • Macrocephaly
      • Prominent scalp veins

    Pulmonary arteriovenous malformations

    In the lungs, pulmonary arteriovenous malformations have no symptoms in up to 29% of cases.

    Genetics

    Can occur due to autosomal dominant diseases, such as Hereditary Hemorrhagic Telangiectasia.

    Pathophysiology

    In a normal functioning human body, arteries carry blood away from the heart to the lungs or the rest of the body, where the blood passes through capillaries, and veins return the blood to heart. An AVM interferes with this process by forming a direct connection of the arteries and veins. AVMs can cause intense pain and lead to serious medical problems. Although AVMs are often associated with the brain and spinal cord, they can develop in any part of the body.

    Arteries and veins are part of the human cardiovascular system. Normally, the arteries in the vascular system carry oxygen-rich blood, except in the case of the pulmonary artery. Structurally, arteries divide and sub-divide repeatedly, eventually forming a sponge-like capillary bed. Blood moves through the capillaries, giving up oxygen and taking up waste products, including CO
    2
    , from the surrounding cells. Capillaries in turn successively join together to form veins that carry blood away. The heart acts to pump blood through arteries and uptake the venous blood.

    An AVM lacks the dampening effect of capillaries on the blood flow, which means that the AVM can get progressively larger over time as the amount of blood flowing through it increases, forcing the heart to work harder to keep up with the extra blood flow. It also causes the surrounding area to be deprived of the functions of the capillaries — removal of CO2 and delivery of nutrients to the cells. The resulting tangle of blood vessels, often called a nidus (Latin for "nest"), has no capillaries. It can be extremely fragile and prone to bleeding because of the abnormally direct connections between high-pressure arteries and low-pressure veins. The resultant sign, audible via stethoscope, is a rhythmic, whooshing sound caused by excessively rapid blood flow through the arteries and veins. It has been given the term "bruit", French for noise. On some occasions a patient with a brain AVM may become aware of the noise, which can compromise hearing and interfere with sleep in addition to causing psychological distress.

    Diagnosis

    An arterial venous malformation of the left kidney and a simple cyst of the right kidney
    An arterial venous malformation of the left kidney leading to aneurysmal dilatation of the left renal vein and inferior vena cava

    AVMs are diagnosed primarily by the following methods:

    • Computerized tomography (CT) scan is a noninvasive X-ray to view the anatomical structures within the brain to detect blood in or around the brain. A newer technology called CT angiography involves the injection of contrast into the blood stream to view the arteries of the brain. This type of test provides the best pictures of blood vessels through angiography and soft tissues through CT.
    • Magnetic resonance imaging (MRI) scan is a noninvasive test, which uses a magnetic field and radio-frequency waves to give a detailed view of the soft tissues of the brain.
    • Magnetic resonance angiography (MRA) - scans created using magnetic resonance imaging to specifically image the blood vessels and structures of the brain. A magnetic resonance angiogram can be an invasive procedure, involving the introduction of contrast dyes (e.g., gadolinium MR contrast agents) into the vasculature of a patient using a catheter inserted into an artery and passed through the blood vessels to the brain. Once the catheter is in place, the contrast dye is injected into the bloodstream and the MR images are taken. Additionally or alternatively, flow-dependent or other contrast-free magnetic resonance imaging techniques can be used to determine the location and other properties of the vasculature.

    AVMs can occur in various parts of the body:

    AVMs may occur in isolation or as a part of another disease (for example, Von Hippel-Lindau disease or hereditary hemorrhagic telangiectasia).

    AVMs have been shown to be associated with aortic stenosis.

    Bleeding from an AVM can be relatively mild or devastating. It can cause severe and less often fatal strokes. If a cerebral AVM is detected before a stroke occurs, usually the arteries feeding blood into the nidus can be closed off to avert the danger. However, interventional therapy may also be relatively risky.

    What is a brain AVM?

    Normally, arteries carry blood containing oxygen from the heart to the brain, and veins carry blood with less oxygen away from the brain and back to the heart. When an arteriovenous malformation (AVM) occurs, a tangle of blood vessels in the brain or on its surface bypasses normal brain tissue and directly diverts blood from the arteries to the veins.

     
     
      
     
     
      

    How common are brain AVMs?

    Brain AVMs occur in less than 1 percent of the general population. It’s estimated that about one in 200–500 people may have an AVM. AVMs are more common in males than in females.

    Why do brain AVMs occur?

    We don’t know why AVMs occur. Brain AVMs are usually congenital, meaning someone is born with one. But they’re usually not hereditary. People probably don’t inherit an AVM from their parents, and they probably won’t pass one on to their children.

    Where do brain AVMs occur?

    Brain AVMs can occur anywhere within the brain or on its covering. This includes the four major lobes of the front part of the brain (frontal, parietal, temporal, occipital), the back part of the brain (cerebellum), the brainstem, or the ventricles (deep spaces within the brain that produce and circulate the cerebrospinal fluid).

     
     
      

    Do brain AVMs change or grow?

    Most AVMs don’t grow or change much, although the vessels involved may dilate (widen). Some AVMs may shrink due to clots in part of the AVM. Some may enlarge to redirect blood in adjacent vessels toward an AVM.

    What are the symptoms of a brain AVM?

    Symptoms may vary depending on where the AVM is located:

    • More than 50 percent of patients with an AVM have an intracranial hemorrhage.
    • Among AVM patients, 20 percent to 25 percent have focal or generalized seizures.
    • Patients may have localized pain in the head due to increased blood flow around an AVM.
    • Fifteen percent may have difficulty with movement, speech and vision.

    What causes brain AVMs to bleed?

    A brain AVM contains abnormal and, therefore, “weakened” blood vessels that direct blood away from normal brain tissue. These abnormal and weak blood vessels dilate over time. Eventually they may burst from the high pressure of blood flow from the arteries, causing bleeding into the brain.

    What are the chances of a brain AVM bleeding?

    The chance of a brain AVM bleeding is 1 percent to 3 percent per year. Over 15 years, the total chance of an AVM bleeding into the brain — causing brain damage and stroke — is 25 percent.

    Does one bleed increase the chance of a second bleed?

    The risk of recurrent intracranial bleeding is slightly higher for a short time after the first bleed. In two studies, the risk during the first year after initial bleeding was 6 percent and then dropped to the baseline rate. In another study, the risk of recurrence during the first year was 17.9 percent. The risk of recurrent bleeding may be even higher in the first year after the second bleed and has been reported to be 25 percent during that year. People who are between 11 to 35 years old and who have an AVM are at a slightly higher risk of bleeding.

    What can happen if a brain AVM causes a bleed?

    The risk of death related to each bleed is 10 percent to 15 percent. The chance of permanent brain damage is 20 percent to 30 percent. Each time blood leaks into the brain, normal brain tissue is damaged. This results in loss of normal function, which may be temporary or permanent. Some possible symptoms include arm or leg weakness/paralysis, or difficulty with speech, vision or memory. The amount of brain damage depends on how much blood has leaked from the AVM.

    What functions does an AVM affect?

    If an AVM bleeds, it can affect one or more normal body functions, depending on the location and extent of the brain injury. Different locations in the brain control different functions:

    • Frontal lobe controls personality.
    • Parietal lobe controls movement of the arms and legs.
    • Temporal lobe controls speech, memory and understanding.
    • Occipital lobe controls vision.
    • The cerebellum controls walking and coordination.
    • Ventricles control the secretion of cerebrospinal fluid.
    • The brainstem controls the pathways from all of the above functions to the rest of the body.

    Are there different types of brain AVMs?

    All blood vessel malformations involving the brain and its surrounding structures are commonly referred to as AVMs. But several types exist:

    • True arteriovenous malformation (AVM). This is the most common brain vascular malformation. It consists of a tangle of abnormal vessels connecting arteries and veins with no normal intervening brain tissue.
    • Occult or cryptic AVM or cavernous malformations. This is a vascular malformation in the brain that doesn’t actively divert large amounts of blood. It may bleed and often produce seizures.
    • Venous malformation. This is an abnormality only of the veins. The veins are either enlarged or appear in abnormal locations within the brain.
    • Hemangioma. These are abnormal blood vessel structures usually found at the surface of the brain and on the skin or facial structures. These represent large and abnormal pockets of blood within normal tissue planes of the body.
    • Dural fistula. The covering of the brain is called the “dura mater.” An abnormal connection between blood vessels that involve only this covering is called a dural fistula. Dural fistulas can occur in any part of the brain covering. Three kinds of dural fistulas are:
      - Dural carotid cavernous sinus fistula. These occur behind the eye and usually cause symptoms because they divert too much blood   toward the eye. Patients have eye swelling, decreased vision, redness and congestion of the eye. They often can hear a “swishing” noise.
      - Transverse-Sigmoid sinus dural fistula. These occur behind the ear. Patients usually complain of hearing a continuous noise (bruit) that occurs with each heartbeat, local pain behind the ear, headaches and neck pain.
      - Sagittal sinus and scalp dural fistula. These occur toward the top of the head. Patients complain of noise (bruit), headaches, and pain near the top of the head; they may have prominent blood vessels on the scalp and above the ear.

    What is the best treatment for a dural fistula?

    The best treatment is usually endovascular surgical blocking of the abnormal connections that have caused the fistula. This involves guiding small tubes (catheters) inside the blood vessel with X-ray guidance and blocking off the abnormal connections. Depending on the location and size, many of these can be treated and cured by these less invasive endovascular techniques.

    How are AVMs diagnosed?

    Most AVMs are detected with either a computed tomography (CT) brain scan or a magnetic resonance imaging (MRI) brain scan. These tests are very good at detecting brain AVMs. They also provide information about the location and size of the AVM and whether it may have bled. A doctor may also perform a cerebral angiogram. This test involves inserting a catheter (small tube) through an artery in the leg (groin). Then it’s guided into each of the vessels in the neck going to the brain, and a contrast material (dye) is injected and pictures are taken of all the blood vessels in the brain. For any type of treatment involving an AVM, an angiogram may be needed to better identify the type of AVM.

    What factors influence whether an AVM should be treated?

    In general, an AVM may be considered for treatment if it has bled, if it’s in an area of the brain that can be easily treated and if it’s not too large.

    What is the best treatment for an AVM?

    It depends on what type it is, the symptoms it may be causing and its location and size.

    What different types of treatment are available?

    • Medical therapy. If there are no symptoms or almost none, or if an AVM is in an area of the brain that can’t be easily treated, conservative medical management may be indicated. If possible, a person with an AVM should avoid any activities that may excessively elevate blood pressure, such as heavy lifting or straining, and avoid blood thinners like warfarin. A person with an AVM should have regular checkups with a neurologist or neurosurgeon.
    • Surgery. If an AVM has bled and/or is in an area that can be easily operated upon, then surgical removal may be recommended. The patient is put to sleep with anesthesia, a portion of the skull is removed, and the AVM is surgically removed. When the AVM is completely taken out, the possibility of any further bleeding should be eliminated.
    • Stereotactic radiosurgery. An AVM that’s not too large, but is in an area that’s difficult to reach by regular surgery, may be treated with stereotactic radiosurgery. In this procedure, a cerebral angiogram is done to localize the AVM. Focused-beam high energy sources are then concentrated on the brain AVM to produce direct damage to the vessels that will cause a scar and allow the AVM to “clot off.”
    • Interventional neuroradiology/endovascular neurosurgery. It may be possible to treat part or all of the AVM by placing a catheter (small tube) inside the blood vessels that supply the AVM and blocking off the abnormal blood vessels with various materials. These include liquid tissue adhesives (glues), micro coils, particles and other materials used to stop blood flowing to the AVM. The best treatment depends on the symptoms the patient is having, what type of AVM is present and the AVM’s size and location.

    What doctors specialize in treating brain AVMs?

    • Vascular neurosurgeons specialize in surgically removing brain AVMs.
    • Radiation therapists/neurosurgeons specialize in the stereotactic radiosurgery treatment of brain AVMs.
    • Interventional neuroradiologists/endovascular neurosurgeons specialize in the endovascular therapy of brain AVMs.
    • Stroke neurologists specialize in the medical management of brain AVMs.
    Neuroradiologists specialize in the diagnosis and imaging of the head, neck, brain and spinal cord. They perform and interpret the CT, MRI, and cerebral angiograms necessary for evaluation, management and treatment. Each of these specialists has had advanced training and is highly skilled at treating complex brain vascular malformations.Image result for avm


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Treatment

Treatment for brain AVMs can be symptomatic, and patients should be followed by a neurologist for any seizures, headaches or focal deficits. AVM-specific treatment may also involve endovascular embolization, neurosurgery or radiosurgery. Embolization, that is, cutting off the blood supply to the AVM with coils or particles or glue introduced by a radiographically guided catheter, may be used in addition to neurosurgery or radiosurgery, but is rarely successful in isolation except in smaller AVMs. Gamma knife may also be used.

The Spetzler-Martin grading system developed at the Barrow Neurological Institute is utilized by neurosurgeons to determine operative versus nonoperative management of AVMs.

Epidemiology

The estimated detection rate of AVM in the US general population is 1.4/100,000 per year.[16] This is approximately one fifth to one seventh the incidence of intracranial aneurysms. An estimated 300,000Americans have AVMs, of whom 12% (approximately 36,000) will exhibit symptoms of greatly varying severity.

How are AVMs and other vascular lesions treated?

There are several options for treating AVMs.  Although medication can often lessen general symptoms such as headache, back pain, and seizures caused by AVMs and other vascular lesions, the definitive treatment for AVMs is either surgery or focused radiation therapy.  Venous malformations and capillary telangiectases rarely require surgery.  Cavernous malformations are usually well defined enough for surgical removal, but surgery on these lesions is less common than for AVMs because they do not pose the same risk of hemorrhage.

Because so many variables are involved in treating AVMs, doctors must assess the danger posed to individuals largely on a case-by-case basis. A hemorrhage from an untreated AVM can cause serious neurological deficits or death, leading many clinicians to recommend surgical intervention whenever the physical characteristics of an AVM appear to indicate a greater-than-usual likelihood of significant bleeding and subsequent neurological damage.  However, surgery on any part of the central nervous system carries some risk of serious complications or death.  There is no easy formula that can allow physicians and individuals to reach a decision on the best course of therapy.

An AVM grading system developed in the mid-1980s can help health care professionals estimate the risk of surgery based on the size of the AVM, location in the brain and surrounding tissue involvement, and any leakage.

Three surgical options are used to treat AVMs:  conventional surgeryendovascular embolization, and radiosurgery.  The choice of treatment depends largely on the size and location of an AVM.   Endovascular embolization and radiosurgery are less invasive than conventional surgery and offer safer treatment options for some AVMs located deep inside the brain.

  • Conventional surgery involves entering the brain or spinal cord and removing the central portion of the AVM, including the fistula, while causing as little damage as possible to surrounding neurological structures.  This surgery is most appropriate when an AVM is located in a superficial portion of the brain or spinal cord and is relatively small in size.  AVMs located deep inside the brain generally cannot be approached through conventional surgical techniques because there is too great a possibility that functionally important brain tissue will be damaged or destroyed.
  • In endovascular embolization the surgeon guides a catheter though the arterial network until the tip reaches the site of the AVM.  The surgeon then injects a substance (such as fast-drying glue-like substances, fibered titanium coils, and tiny balloons) that will travel through blood vessels and create an artificial blood clot in the center of an AVM.  Since embolization usually does not permanently obliterate the AVM, it is usually used as an adjunct to surgery or to radiosurgery to reduce the blood flow through the AVM and make the surgery safer.
  • Radiosurgery is an even less invasive therapeutic approach often used to treat small AVMs that haven’t ruptured.  A beam of highly focused radiation is aimed directly on the AVM and damages the walls of the blood vessels making up the lesion.  Over the course of the next several months, the irradiated vessels gradually degenerate and eventually close, leading to the resolution of the AVM.

Embolization frequently proves incomplete or temporary, although new embolization materials have led to improved results.  Radiosurgery often has incomplete results as well, particularly when an AVM is large, and it poses the additional risk of radiation damage to surrounding normal tissues.  Even when successful, complete closure of an AVM takes place over the course of many months following radiosurgery.  During that period, the risk of hemorrhage is still present.  However, both techniques can treat deeply situated AVMs that had previously been inaccessible.  And in many individuals, staged embolization followed by conventional surgical removal or by radiosurgery is now performed, resulting in further reductions in death and complication rates.

Surgical Treatment of Brain Arteriovenous Malformations (AVM) An AVM is composed of an abnormal collection of blood vessels with weakened walls. These abnormal blood vessels have a tendency to bleed.

AVM stands for Arteriovenous Malformation. An AVM is a tangle of abnormal and poorly formed blood vessels (arteries and veins). They have a higher rate of bleeding than normal vessels. AVMs can occur anywhere in the body. Brain AVMs are of special concern because of the damage they cause when they bleed.

Treatment

Treatment for brain AVMs can be symptomatic, and patients should be followed by a neurologist for any seizures, headaches or focal deficits. AVM-specific treatment may also involve endovascular embolization, neurosurgery or radiosurgery. Embolization, that is, cutting off the blood supply to the AVM with coils or particles or glue introduced by a radiographically guided catheter, may be used in addition to neurosurgery or radiosurgery, but is rarely successful in isolation except in smaller AVMs. Gamma knife may also be used.

The Spetzler-Martin grading system developed at the Barrow Neurological Institute is utilized by neurosurgeons to determine operative versus nonoperative management of AVMs.

Epidemiology

The estimated detection rate of AVM in the US general population is 1.4/100,000 per year.[16] This is approximately one fifth to one seventh the incidence of intracranial aneurysms. An estimated 300,000Americans have AVMs, of whom 12% (approximately 36,000) will exhibit symptoms of greatly varying severity.

How are AVMs and other vascular lesions treated?

There are several options for treating AVMs.  Although medication can often lessen general symptoms such as headache, back pain, and seizures caused by AVMs and other vascular lesions, the definitive treatment for AVMs is either surgery or focused radiation therapy.  Venous malformations and capillary telangiectases rarely require surgery.  Cavernous malformations are usually well defined enough for surgical removal, but surgery on these lesions is less common than for AVMs because they do not pose the same risk of hemorrhage.

Because so many variables are involved in treating AVMs, doctors must assess the danger posed to individuals largely on a case-by-case basis. A hemorrhage from an untreated AVM can cause serious neurological deficits or death, leading many clinicians to recommend surgical intervention whenever the physical characteristics of an AVM appear to indicate a greater-than-usual likelihood of significant bleeding and subsequent neurological damage.  However, surgery on any part of the central nervous system carries some risk of serious complications or death.  There is no easy formula that can allow physicians and individuals to reach a decision on the best course of therapy.

An AVM grading system developed in the mid-1980s can help health care professionals estimate the risk of surgery based on the size of the AVM, location in the brain and surrounding tissue involvement, and any leakage.

Three surgical options are used to treat AVMs:  conventional surgeryendovascular embolization, and radiosurgery.  The choice of treatment depends largely on the size and location of an AVM.   Endovascular embolization and radiosurgery are less invasive than conventional surgery and offer safer treatment options for some AVMs located deep inside the brain.

  • Conventional surgery involves entering the brain or spinal cord and removing the central portion of the AVM, including the fistula, while causing as little damage as possible to surrounding neurological structures.  This surgery is most appropriate when an AVM is located in a superficial portion of the brain or spinal cord and is relatively small in size.  AVMs located deep inside the brain generally cannot be approached through conventional surgical techniques because there is too great a possibility that functionally important brain tissue will be damaged or destroyed.
  • In endovascular embolization the surgeon guides a catheter though the arterial network until the tip reaches the site of the AVM.  The surgeon then injects a substance (such as fast-drying glue-like substances, fibered titanium coils, and tiny balloons) that will travel through blood vessels and create an artificial blood clot in the center of an AVM.  Since embolization usually does not permanently obliterate the AVM, it is usually used as an adjunct to surgery or to radiosurgery to reduce the blood flow through the AVM and make the surgery safer.
  • Radiosurgery is an even less invasive therapeutic approach often used to treat small AVMs that haven’t ruptured.  A beam of highly focused radiation is aimed directly on the AVM and damages the walls of the blood vessels making up the lesion.  Over the course of the next several months, the irradiated vessels gradually degenerate and eventually close, leading to the resolution of the AVM.

Embolization frequently proves incomplete or temporary, although new embolization materials have led to improved results.  Radiosurgery often has incomplete results as well, particularly when an AVM is large, and it poses the additional risk of radiation damage to surrounding normal tissues.  Even when successful, complete closure of an AVM takes place over the course of many months following radiosurgery.  During that period, the risk of hemorrhage is still present.  However, both techniques can treat deeply situated AVMs that had previously been inaccessible.  And in many individuals, staged embolization followed by conventional surgical removal or by radiosurgery is now performed, resulting in further reductions in death and complication rates.

Surgical Treatment of Brain Arteriovenous Malformations (AVM) An AVM is composed of an abnormal collection of blood vessels with weakened walls. These abnormal blood vessels have a tendency to bleed.

AVM stands for Arteriovenous Malformation. An AVM is a tangle of abnormal and poorly formed blood vessels (arteries and veins). They have a higher rate of bleeding than normal vessels. AVMs can occur anywhere in the body. Brain AVMs are of special concern because of the damage they cause when they bleed.

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